The history of the 780th Military Intelligence Brigade dates back to 1998 when the 704th Military Intelligence (MI) Brigade was tasked to develop a computer network operations force for the Army. In June 1998, B Company, 742nd MI Battalion answered that call.

In June 2000, Detachment Meade, 742nd MI Battalion was established to sustain the growing need for an Army computer network operations force. Detachment Meade was re-designated as the Army Network Warfare Detachment in 2007 and later as the Computer Network Operations Task Force. In June 2008 the Task Force was again re-designated as the Army Network Warfare Battalion (Provisional). The following year the battalion moved beyond its provisional status and was designated the 744th MI Battalion (Army Network Warfare Battalion).

In December 2010, the Army approved the establishment of a cyberspace operations brigade, and on October 1, 2011, the 780th MI Brigade was organized. Subsequently, the 744th MI Battalion was re-designated as the 781st MI Battalion and re-organized under the new brigade. The 780th MI Brigade officially unfurled its colors for the first time during a ceremony at Fort. Meade, Maryland on December 1, 2011.

The brigade began building a second battalion headquartered at Fort Gordon, Georgia in 2011 culminating with the stand-up and designation of the 782nd MI Battalion in June 2012. Detachments Texas and Hawaii were organized as part of the 782nd MI Battalion in 2013 and 2014 respectively giving the brigade a footprint in four states in support of multiple operational headquarters.

In July 2017, the 780th MI Brigade established the Cyber Solutions Development Detachment. The Detachment takes its place as the newest addition to the brigade focused on innovative solutions across the spectrum of cyberspace operations.

Since August 15, 2017, U.S. Army National Guard Soldiers have been mobilized and assigned to Task Force Echo, an organization conducting cyberspace operations in support of U.S. Cyber Command and the Cyber National Mission Force. The Task Force is aligned under the 780th MI Brigade, which falls under the operational control of ARCYBER.

On June 6, 2018, the Department of the Army directed U.S. Army Cyber Command to activate the 915th Cyberspace Warfare Battalion (915 CWB). Subsequently, ARCYBER directed the 780th MI Brigade assume Command Authority and administrative control of the 915th CWB. The 915 CWB is the first scalable organic expeditionary capability to meet the Army’s current and projected tactical cyberspace requirements, including the integration of cyber and electronic warfare.